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Glipizide Indication.
For use as an adjunct to diet for the control of hyperglycemia and its associated symptomatology in patients with non-insulin-dependent diabetes mellitus (NIDDM; type II), formerly known as maturity-onset diabetes, after an adequate trial of dietary therapy has proved unsatisfactory.
Glipizide Contraindications.
1. Known hypersensitivity to the drug.
2. Diabetic ketoacidosis, with or without coma. This condition should be treated with insulin.
Glipizide Prescription.
Glipizide is prescribed to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in the blood), particularly in people whose diabetes cannot be controlled by diet alone. Glipizide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be capable of producing insulin for Glipizide to work. Glipizide is not used to treat type 1 diabetes (condition in which the body does not produce insulin and therefore cannot control the amount of sugar in the blood).
An oral hypoglycemic agent which is rapidly absorbed and completely metabolized.
How should Glipizide be used?
Glipizide comes in tablets to take by mouth. It is usually taken once a day, 30 minutes before breakfast.
Glipizide, a second-generation sulfonylurea, is used with diet to lower blood glucose in patients with diabetes mellitus type II. The primary mode of action of glipizide in experimental animals appears to be the stimulation of insulin secretion from the beta cells of pancreatic islet tissue and is thus dependent on functioning beta cells in the pancreatic islets. In humans glipizide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. In man, stimulation of insulin secretion by glipizide in response to a meal is undoubtedly of major importance. Fasting insulin levels are not elevated even on long-term glipizide administration, but the postprandial insulin response continues to be enhanced after at least 6 months of treatment. Some patients fail to respond initially, or gradually lose their responsiveness to sulfonylurea drugs, including glipizide.
Glipizide side effects.
You may experience hypoglycemia (low blood sugar) while you are taking Glipizide. Your doctor will tell you what you should do if you develop hypoglycemia. He or she may tell you to check your blood sugar, eat or drink a food or beverage that contains sugar, such as hard candy or fruit juice, or get medical care. Follow these directions carefully if you have any of the following symptoms of hypoglycemia:
- clumsy or jerky movements;
- dizziness or lightheadedness;
- headache;
- hunger;
- nervousness or irritability;
- numbness or tingling around the mouth;
- pale skin;
- shakiness;
- sudden changes in behavior or mood;
- sweating;
- weakness;
If hypoglycemia is not treated, severe symptoms may develop. Be sure that your family, friends, and other people who spend time with you know that if you have any of the following symptoms, they should get medical treatment for you immediately.
- confusion;
- loss of consciousness;
- seizures;
Call your doctor immediately if you have any of the following symptoms of hyperglycemia (high blood sugar):
- blurred vision;
- extreme hunger;
- extreme thirst;
- frequent urination;
- weakness;
If high blood sugar is not treated, a serious, life-threatening condition called diabetic ketoacidosis could develop. Call your doctor immediately if you have any of the these symptoms:
- breath that smells fruity;
- decreased consciousness;
- dry mouth;
- shortness of breath;
- upset stomach and vomiting;
Glipizide may cause side effects. If you experience any of the following symptoms, call your doctor immediately:
- dark urine;
- exaggerated sunburn;
- fever;
- itching or redness;
- light-colored stools;
- skin rash;
- sore throat;
- unusual bleeding or bruising;
- yellowing of the skin or eyes;
