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Flutamide Indication.
For the management of locally confined Stage B2-C and Stage D2 metastatic carcinoma of the prostate
Flutamide Contraindications.
Flutamide Capsules are contraindicated in patients who are hypersensitive to flutamide or any component of this preparation.
Flutamide Capsules are contraindicated in patients with severe hepatic impairment (baseline hepatic enzymes should be evaluated prior to treatment.
Flutamide is used to treat:
* prostate cancer
Flutamide is in a class of drugs known as antiandrogens. It blocks the activity of testosterone, a hormone produced by the body.
An antiandrogen with about the same potency as cyproterone in rodent and canine species.
Flutamide is a nonsteroidal antiandrogen. In animal studies, flutamide demonstrates potent antiandrogenic effects. It exerts its antiandrogenic action by inhibiting androgen uptake and/or by inhibiting nuclear binding of androgen in target tissues or both. Prostatic carcinoma is known to be androgen-sensitive and responds to treatment that counteracts the effect of androgen and/or removes the source of androgen, e.g. castration. Elevations of plasma testosterone and estradiol levels have been noted following flutamide administration.
Flutamide side effects.
- breast tenderness or enlargement;
- decrease in appetite;
- decrease in sexual desire or ability;
- depression;
- diarrhea;
- fast heartbeat;
- hot flashes or sudden sweating;
- nervousness;
- sensitivity to sunlight;
- shortness of breath;
- skin rash;
- swelling of the feet or hands;
- weakness;
