Fenofibrate Indication.
For use as adjunctive therapy to diet to reduce elevated LDL-C, Total-C,Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb)
Fenofibrate Contraindications.
Fenofibrate is contraindicated in patients who exhibit hypersensitivity to fenofibrate.
Fenofibrate is contraindicated in patients with hepatic or severe renal dysfunction, including primary biliary cirrhosis, and patients with unexplained persistent liver function abnormality.
Fenofibrate is contraindicated in patients with preexisting gallbladder disease.
Fenofibrate Prescription.
Fenofibrate is prescribed with diet changes (restriction of cholesterol and fat intake) to reduce the amount of cholesterol and triglycerides (fatty substances) in your blood. Accumulation of cholesterol and fats along the walls of your arteries (a process known as atherosclerosis) decreases blood flow and, therefore, the oxygen supply to your heart, brain, and other parts of your body. Lowering your blood level of cholesterol and fats may help to prevent heart disease, angina (chest pain), strokes, and heart attacks.
An antilipemic agent which reduces both cholesterol and triglycerides in the blood.
How should Fenofibrate be used?
Fenofibrate comes as a capsule to take by mouth. It is usually taken once a day with a meal.
Fenofibrate is a lipid regulating agent indicated as adjunctive therapy to diet to reduce elevated LDL-C, Total-C, Triglycerides and Apo B, and to increase HDL-C in adult patients with primary hypercholesterolemia or mixed dyslipidemia (Fredrickson Types IIa and IIb). Fenofibrate is also indicated as adjunctive therapy to diet for treatment of adult patients with hypertriglyceridemia (Fredrickson Types IV and V hyperlipidemia). Fenofibric acid, the active metabolite of Fenofibrate, produces reductions in total cholesterol, LDL cholesterol, apolipoprotein B, total triglycerides and triglyceride rich lipoprotein (VLDL) in treated patients. In addition, treatment with fenofibrate results in increases in high density lipoprotein (HDL) and apoproteins apoAI and apoAII.
Fenofibrate side effects.
- constipation;
- dizziness or lightheadedness;
- fatigue;
- flu-like symptoms;
- gas;
- headache;
- infection;
- joint pain;
- muscle pain or tenderness;
- rash;
- runny nose;
- stomach pain;
- upset stomach;
- weakness;
