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Efavirenz Indication.
For use in combination treatment of HIV infection (AIDS).
Efavirenz Contraindications.
Efavirenz is contraindicated in patients with clinically significant hypersensitivity to any of its components.
Efavirenz should not be administered concurrently with astemizole, cisapride, midazolam, triazolam, or ergot derivatives because competition for CYP3A4 by efavirenz could result in inhibition of metabolism of these drugs and create the potential for serious and/or life-threatening adverse events (eg, cardiac arrhythmias, prolonged sedation, or respiratory depression). Efavirenz should not be administered concurrently with voriconazole because Efavirenz significantly decreases voriconazole plasma concentrations.
Efavirenz Prescription.
Efavirenz is prescribed with other prescriptions to treat human immunodeficiency virus (HIV) infection in patients with or without acquired immunodeficiency syndrome (AIDS). Efavirenz is in a class of prescriptions called nonnucleoside reverse transcriptase inhibitors (NNRTIs). Efavirenz works by slowing the spread of HIV in the body. Efavirenz does not cure HIV infection and may not prevent you from developing HIV-related illnesses. Efavirenz does not prevent you from spreading HIV to other people.
Efavirenz (brand names EfavirenzAR and StocrinAR) is a non-nucleoside reverse transcriptase inhibitor (NNRTI) and is used as part of highly active antiretroviral therapy (HAART) for the treatment of a human immunodeficiency virus (HIV) type 1.
For HIV infection that has not previously been treated, efavirenz and lamivudine in combination with zidovudine or tenofovir is the preferred NNRTI-based regimen.
Efavirenz is also used in combination with other antiretroviral agents as part of an expanded postexposure prophylaxis regimen to prevent HIV transmission for those exposed to materials associated with a high risk for HIV transmission.
How should Efavirenz be used?
Efavirenz comes as a capsule and as a tablet to take by mouth. It is usually taken once a day with plenty of water on an empty stomach. Take efavirenz at around the same time every day. Taking efavirenz at bedtime may make side effects less bothersome.
Efavirenz controls HIV infection, but does not cure it.
Efavirenz (dideoxyinosine, ddI) is an oral nucleoside reverse transcriptase inhibitor (NRTI). It is a synthetic purine derivative and, similar to zidovudine, zalcitabine, and stavudine. Efavirenz was originally approved specifically for the treatment of HIV infections in patients who failed therapy with zidovudine. Currently, the CDC recommends that Efavirenz be given as part of a three-drug regimen that includes another nucleoside reverse transcriptase inhibitor (e.g., lamivudine, stavudine, zidovudine) and a protease inhibitor or efavirenz when treating HIV infection.
Efavirenz side effects.
- abnormally happy mood;
- blisters or sores on skin;
- confusion;
- diarrhea;
- difficulty concentrating;
- difficulty falling asleep or staying asleep;
- dizziness;
- drowsiness;
- extreme tiredness;
- fainting;
- flu-like symptoms;
- forgetfulness;
- hallucinations (seeing things or hearing voices that do not exist);
- headache;
- headache;
- indigestion;
- itching;
- lack of energy;
- loss of appetite;
- movements of your body that you cannot control;
- nervousness;
- pain;
- pain in the upper right part of the stomach;
- peeling skin;
- rash;
- seizures;
- sore throat, cough, fever, chills, or other signs of infection;
- stomach pain;
- strange thoughts;
- unusual bleeding or bruising;
- unusual dreams;
- upset stomach;
- vomiting;
- yellowing of the skin or eyes;
