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Duloxetine Indication.
For the treatment of major depressive disorder (MDD).
Duloxetine Prescription.
Duloxetine is prescribed to treat depression and generalized anxiety disorder (GAD; excessive worry and tension that disrupts daily life and lasts for 6 months or longer). Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes). Duloxetine is in a class of prescriptions called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs). It works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance and stop the movement of pain signals in the brain.
Duloxetine (brand names Duloxetine, Yentreve, and in parts of Europe, Xeristar or Ariclaim) is a drug which primarily targets major depressive disorder (MDD), generalized anxiety disorder (GAD), pain related to diabetic peripheral neuropathy and in some countries stress urinary incontinence (SUI). It is manufactured and marketed by Eli Lilly and Company.
Duloxetine has not yet been FDA approved for stress urinary incontinence or for fibromyalgia.
Duloxetine is a selective SNRI (selective serotonin-norepinephrine reuptake inhibitor). Duloxetine is a systemic drug therapy which affects the body as a whole. Known also under the code name LY248686, it is a potent dual reuptake inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE), possessing comparable affinities in binding to NE- and 5-HT transporter sites. It is a less potent inhibitor of dopamine reuptake.
How should Duloxetine be used?
Duloxetine comes as a delayed release (long-acting) capsule to take by mouth. When duloxetine is used to treat depression, it is usually taken once or twice a day with or without food. When duloxetine is used to treat generalized anxiety disorder or the pain of diabetic neuropathy, it is usually taken once a day with or without food. Take duloxetine at around the same time(s) every day.
Swallow the capsules whole; do not split, chew, or crush them. Do not open the capsules and mix the contents with liquids or sprinkle the contents on food.
If you are taking duloxetine to treat generalized anxiety disorder or the pain of diabetic neuropathy, your doctor may start you on a low dose of prescription and gradually increase your dose.
Duloxetine may help control your symptoms but will not cure your condition. It may take 1 to 4 weeks or longer before you feel the full benefit of duloxetine.
Duloxetine is in a class of prescriptions called selective serotonin and norepinephrine reuptake inhibitors (SSNRIs) and primarily targets major depressive disorders (MDD) and stress urinary incontinence (SUI). Duloxetine is also used to treat pain and tingling caused by diabetic neuropathy (damage to nerves that can develop in people who have diabetes). Known also as LY248686, it is a potent dual inhibitor of serotonin (5-hydroxytryptamine, 5-HT) and norepinephrine (NE) reuptake, possessing comparable affinities in binding to NE and 5-HT transport sites. Interestingly, its behavior contrasts to most other dual-reuptake inhibitors. Furthermore, duloxentine lacks affinity for monoamine receptors within the central nervous system.
Duloxetine side effects.
- agitation;
- blisters;
- blurred vision;
- changes in sexual desire or ability;
- constipation;
- dark colored urine;
- decreased appetite;
- diarrhea;
- difficulty breathing or swallowing;
- difficulty urinating;
- dizziness;
- drowsiness;
- dry mouth;
- extreme tiredness;
- fast heartbeat;
- fever;
- flu-like symptoms;
- hallucinating (seeing things or hearing voices that do not exist);
- headache;
- heartburn;
- hives;
- increased urination;
- itching;
- loss of coordination;
- muscle pain or cramps;
- nausea;
- pain in the upper right part of the stomach;
- rash;
- seizures;
- stomach pain;
- sweating or night sweats;
- swelling of the eyes, face, lips, tongue, throat, hands, arms, feet, ankles, or lower legs;
- uncontrollable shaking of a part of the body;
- unusual bruising or bleeding;
- vomiting;
- weakness;
- yellowing of the skin or eyes;
