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Didanosine Indication.
For use, in combination with other antiretroviral agents, in the treatment of HIV-1 infection in adults.
Didanosine Contraindications.
DidanosineEC (didanosine) is contraindicated in patients with previously demonstrated clinically significant hypersensitivity to any component of the formulation.
Didanosine Prescription.
Didanosine is prescribed with other prescription to treat human immunodeficiency virus (HIV) infection in patients with or without acquired immunodeficiency syndrome (AIDS). Didanosine is in a class of prescription called nucleoside reverse transcriptase inhibitors (NRTIs). Didanosine works by slowing the spread of HIV in the body. Didanosine does not cure HIV infection and may not prevent you from developing HIV-related illnesses. Didanosine does not prevent you from spreading HIV to other people.
A dideoxynucleoside compound in which the 3&
How should Didanosine be used?
Didanosine comes as extended-release (long-acting) capsules, tablets that can be chewed or mixed with water, a powder to be mixed with water, and a solution (liquid). All are taken by mouth. Didanosine is usually taken once or twice a day on an empty stomach, 30 minutes before or 2 hours after eating. To help you remember to take didanosine, take it around the same time(s) every day.
If you are using the extended-release capsules, swallow them whole; do not split, chew, crush, or open them.
If you are using the tablets, do not swallow them whole. Chew the tablets well or mix them in at least 1 ounce of water and stir well to dissolve the tablets before swallowing. You may add one ounce (2 tablespoonfuls) of clear apple juice to the mixture for flavor, if needed. Do not use any other kind of juice. Drink all of the liquid right away.
If you are using the powder, you must mix it with water immediately before you take it. Open the packet and pour the powder into a glass with four ounces (1/2 cup) of water. Stir the mixture for 2 or 3 minutes until the powder is completely dissolved. Drink all of the liquid right away. Do not mix the powder with fruit juice or any other liquid.
If you are using the solution, you should shake it well before each use to mix the prescription evenly. Use a dose-measuring spoon or cup to measure the correct dose, not a regular household spoon.
Didanosine controls HIV infection but does not cure it.
Didanosine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Didanosine differs from other nucleoside analogues, as it does not have any of the regular bases, instead it has hypoxanthine attached to the sugar ring. Didanosine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. Didanosine is effective against HIV, and usually used in combination with other antiviral therapy. Switching from long term AZT treatment to didanosine has been shown to be beneficial. Didanosine has weak acid stability and therefore, it is often combined with an antacid.
Didanosine side effects.
- blurred vision;
- chills;
- dark yellow or brown urine;
- deep or rapid breathing;
- diarrhea;
- diarrhea;
- difficulty breathing or swallowing;
- difficulty in seeing colors clearly;
- dizziness;
- extreme tiredness;
- fast heart beat;
- feeling cold;
- fever;
- flu-like symptoms;
- headache;
- hives;
- itching;
- light-headedness;
- loss of appetite;
- muscle pain;
- numbness, tingling, burning, or pain in hands or feet;
- severe back pain;
- shortness of breath;
- skin rash;
- stomach pain;
- sudden development of a slow or irregular heartbeat;
- swelling of the stomach;
- unusual bleeding or bruising;
- upset stomach;
- vomiting;
- weakness;
- yellowing of the skin or eyes;
