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Clomiphene Indication.
Used mainly in female infertility due to anovulation (e.g. due to polycystic ovary syndrome). In some countries, it is also registered for use in men.
Clomiphene Contraindications.
Clomiphene is contraindicated in patients with a known hypersensitivity or allergy to clomiphene citrate or to any of its ingredients.
Clomiphene Prescription.
Clomiphene is prescribed to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant. Clomiphene is in a class of prescription called ovulatory stimulants. It works similarly to estrogen, a female hormone that causes eggs to develop in the ovaries and be released.
A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.
How should Clomiphene be used?
Clomiphene comes as a tablet to take by mouth. It is usually taken once a day for 5 days, beginning on or about day 5 of the cycle. To help you remember to take clomiphene, take it around the same time every day.
Clomiphene is an orally administered, non steroidal, ovulatory stimulant that acts as a selective estrogen receptor modulator (SERM). Clomiphene can lead to multiple ovulation, and hence increasing the risk of twins. In comparison to purified FSH, the rate of ovarian hyperstimulation syndrome is low. There may be an increased risk of ovarian cancer, and weight gain. Clomiphene is capable of interacting with estrogen-receptor-containing tissues, including the hypothalamus, pituitary, ovary, endometrium, vagina, and cervix. It may compete with estrogen for estrogen-receptor-binding sites and may delay replenishment of intracellular estrogen receptors. Clomiphene initiates a series of endocrine events culminating in a preovulatory gonadotropin surge and subsequent follicular rupture. The first endocrine event in response to a course of clomifene therapy, is an increase in the release of pituitary gonadotropins. This initiates steroidogenesis and folliculogenesis resulting in growth of the ovarian follicle and an increase in the circulating level of estradiol. Following ovulation, plasma progesterone and estradiol rise and fall as they would in a normal ovulatory cycle.
Clomiphene side effects.
- abnormal vaginal bleeding;
- blind spots;
- blurred vision;
- breast discomfort;
- double vision;
- flushing (feeling of warmth);
- headache;
- hot flashes;
- shortness of breath;
- stomach or lower stomach pain;
- stomach swelling;
- upset stomach;
- visual spots or flashes;
- vomiting;
- weight gain;
