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Clarithromycin Indication.
For the treatment of bacterial infection of (pharyngitis/tonsillitis, sinusitis, bronchitis, pneumonia, uncomplicated skin and skin structure infections) caused by H. influenzae, M. catarrhalis, M. pneumoniae, S. pneumoniae, C. pneumoniae (TWAR), S. aureus, S. pyogenes, Mycobacterium avium and Mycobacterium intracellulare
Clarithromycin Contraindications.
Clarithromycin is contraindicated in patients with a known hypersensitivity to clarithromycin, erythromycin, or any of the macrolide antibiotics.
Concomitant administration of clarithromycin with cisapride, pimozide, or terfenadine is contraindicated. There have been post-marketing reports of drug interactions when clarithromycin and/or erythromycin are co-administered with cisapride, pimozide, or terfenadine resulting in cardiac arrhythmias (QT prolongation, ventricular tachycardia, ventricular fibrillation, and torsades de pointes) most likely due to inhibition of hepatic metabolism of these drugs by erythromycin and clarithromycin. Fatalities have been reported.
Clarithromycin Prescription.
Clarithromycin is prescribed to treat certain infections caused by bacteria, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the ears, sinuses, skin, and throat. It also is used to treat and prevent disseminated Mycobacterium avium complex (MAC) infection (a type of lung infection that often affects people with human immunodeficiency virus (HIV)). It is used in combination with other prescription to eliminate H. pylori, a bacteria that causes ulcers. Clarithromycin is in a class of prescription called macrolide antibiotics. It works by stopping the growth of bacteria. Antibiotics will not work for colds, flu, or other viral infections.
A semisynthetic macrolide antibiotic derived from erythromycin that is active against a variety of microorganisms. It can inhibit protein synthesis in bacteria by reversibly binding to the 50S ribosomal subunits. This inhibits the translocation of aminoacyl transfer-RNA and prevents peptide chain elongation.
How should Clarithromycin be used?
Clarithromycin comes as a tablet, an extended-release (long-acting) tablet, and a suspension (liquid) to take by mouth. The regular tablet and liquid are usually taken with or without food every 12 hours (twice a day) for 7-14 days. The long-acting tablet is usually taken with food every 24 hours (once a day) for 7-14 days. Take clarithromycin at around the same time(s) every day.
Shake the liquid well before each use to mix the prescription evenly.
The tablets should be taken with a full glass of water. Swallow the long-acting tablets whole; do not split, chew, or crush them.
Clarithromycin, a macrolide antibiotic similar to erythromycin and azithromycin, is effective against Mycobacterium avium complex (MAC) and is used for the treatment of Helicobacter pylori-associated peptic ulcer disease, community-acquired pneumonia, sinusitis, and chronic bronchitis. Clarithromycin is also used to treat respiratory tract, sexually transmitted, otitis media, and AIDS-related infections.
Take clarithromycin until you finish the prescription, even if you feel better. If you stop taking clarithromycin too soon, your infection may not be completely treated and the bacteria may become resistant to antibiotics.
Clarithromycin side effects.
- abnormal taste;
- blisters or red splotches on skin;
- diarrhea;
- difficulty breathing or swallowing;
- fast, pounding, or irregular heartbeat;
- fever;
- flu-like symptoms;
- headache;
- heartburn;
- hives;
- hoarseness;
- itching;
- lack of energy;
- nausea;
- pain in the upper right part of the stomach;
- rash;
- stomach pain;
- swelling of the face, throat, tongue, lips, eyes, hands, feet, ankles, or lower legs;
- unusual bruising or bleeding;
- yellowing of the skin or eyes;
