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Carvedilol Indication.
For the treatment of mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin.
Carvedilol Contraindications.
Carvedilol is contraindicated in patients with bronchial asthma (2 cases of death from status asthmaticus have been reported in patients receiving single doses of Carvedilol) or related bronchospastic conditions, second- or third-degree AV block, sick sinus syndrome or severe bradycardia (unless a permanent pacemaker is in place), or in patients with cardiogenic shock or who have decompensated heart failure requiring the use of intravenous inotropic therapy. Such patients should first be weaned from intravenous therapy before initiating Carvedilol.
Use of Carvedilol in patients with clinically manifest hepatic impairment is not recommended.
Carvedilol is contraindicated in patients with hypersensitivity to any component of the product.
Carvedilol Prescription.
Carvedilol is prescribed to treat heart failure (condition in which the heart cannot pump enough blood to all parts of the body) and high blood pressure. It also is used to treat people whose hearts cannot pump blood well as a result of a heart attack. Carvedilol is often used in combination with other prescription. Carvedilol is in a class of prescription called beta-blockers. It works by relaxing the blood vessels to allow blood to flow through the body more easily.
Carvedilol is a non-selective beta blocker indicated in the treatment of mild to moderate congestive heart failure (CHF). It blocks beta-1 and beta-2 adrenergic receptors as well as the alpha-1 adrenergic receptors.
How should Carvedilol be used?
Carvedilol comes as a tablet and an extended-release (long-acting) capsule to take by mouth. The tablet is usually taken twice a day with food. The extended-release capsule is usually taken once a day in the morning with food. Try to take carvedilol at around the same time(s) every day.
Swallow the extended-release capsules whole. Do not chew or crush the capsules, and do not divide the beads inside a capsule into more than one dose. If you are unable to swallow the capsules, you may carefully open a capsule and sprinkle all of the beads it contains over a spoonful of cool or room temperature applesauce. Swallow the entire mixture immediately without chewing.
Your doctor will probably start you on a low dose of carvedilol and gradually increase your dose to allow your body to adjust to the prescription. Talk to your doctor about how you feel and about any symptoms you experience during this time.
Carvedilol may help to control your condition but will not cure it. Continue taking carvedilol even if you feel well. Do not stop taking carvedilol without talking to your doctor. If you suddenly stop taking carvedilol, you may experience serious heart problems such as severe chest pain, a heart attack, or an irregular heartbeat. Your doctor will probably want to decrease your dose gradually over 1 to 2 weeks. Your doctor will watch you carefully and will probably tell you to avoid physical activity during this time.
Carvedilol is a nonselective beta-adrenergic blocking agent with alpha1-blocking activity and is indicated for the treatment of hypertension and mild or moderate (NYHA class II or III) heart failure of ischemic or cardiomyopathic origin. Carvedilol is a racemic mixture in which nonselective b-adrenoreceptor blocking activity is present in the S(-) enantiomer and a-adrenergic blocking activity is present in both R(+) and S(-) enantiomers at equal potency. Carvedilol has no intrinsic sympathomimetic activity. The effect of carvedilol's b-adrenoreceptor blocking activity has been demonstrated in animal and human studies showing that carvedilol (1) reduces cardiac output in normal subjects; (2) reduces exercise-and/or isoproterenol-induced tachycardia and (3) reduces reflex orthostatic tachycardia.
Carvedilol side effects.
- chest pain;
- cough;
- diarrhea;
- difficulty breathing;
- difficulty breathing and swallowing;
- difficulty falling asleep or staying asleep;
- dizziness;
- dry eyes;
- fainting;
- headache;
- hives;
- itching;
- joint pain;
- lightheadedness;
- loss of consciousness;
- nausea;
- numbness, burning, or tingling in the arms or legs;
- rash;
- seizures;
- shortness of breath;
- slow heartbeat;
- slow or irregular heartbeat;
- swelling of the arms, hands, feet, ankles, or lower legs;
- tiredness;
- vision changes;
- vomiting;
- weakness;
- weight gain;
