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Amitriptyline Indication.
For the treatment of anxiety, bipolar disorders, and depression.
Amitriptyline Contraindications.
Amitriptyline HCl is contraindicated in patients who have shown prior hypersensitivity to it.
Amitriptyline Prescription.
Amitriptyline is prescribed to treat symptoms of depression. Amitriptyline is in a class of prescription called tricyclic antidepressants. It works by increasing the amounts of certain natural substances in the brain that are needed to maintain mental balance.
Tricyclic antidepressant with anticholinergic and sedative properties. It appears to prevent the re-uptake of norepinephrine and serotonin at nerve terminals, thus potentiating the action of these neurotransmitters. Amitriptyline also appears to antagonize cholinergic and alpha-1 adrenergic responses to bioactive amines.
How should Amitriptyline be used?
Amitriptyline comes as a tablet to take by mouth. It is usually taken one to four times a day. Take amitriptyline at around the same time(s) every day.
Your doctor will probably start you on a low dose of amitriptyline and gradually increase your dose.
It may take a few weeks or longer before you feel the full benefit of amitriptyline.
Amitriptyline, a tertiary amine tricyclic antidepressant, is structurally related to both the skeletal muscle relaxant cyclobenzaprine and the thioxanthene antipsychotics such as thiothixene. It is extremely sedating, and thus improvement of sleep patterns can be the first benefit of treatment. Amitriptyline exhibits strong anticholinergic activity, cardiovascular effects including orthostatic hypotension, changes in heart rhythm and conduction, and a lowering of the seizure threshold. As with other antidepressants, several weeks of therapy may be required in order to realize the full clinical benefit of amitriptyline. Although not a labelled indication, amitriptyline is widely used in the management of chronic nonmalignant pain (e.g., post-herpetic neuralgia, fibromyalgia).
Amitriptyline side effects.
- agitation;
- blurred vision;
- changes in appetite or weight;
- changes in sex drive or ability;
- cold body temperature;
- coma (loss of consciousness for a period of time);
- confusion;
- constipation;
- crushing chest pain;
- difficulty urinating;
- dizziness or faintness;
- drowsiness;
- dry mouth;
- excessive sweating;
- fainting;
- fever;
- hallucinating (seeing things or hearing voices that do not exist);
- headaches;
- irregular heartbeat;
- jaw, neck, and back muscle spasms;
- nausea;
- nightmares;
- pain, burning, or tingling in the hands or feet;
- problems concentrating;
- rapid, pounding, or irregular heartbeat;
- rigid muscles;
- seizures;
- severe skin rash or hives;
- slow or difficult speech;
- swelling of the face and tongue;
- uncontrollable shaking of a part of the body;
- unsteadiness;
- unusual bleeding or bruising;
- vomiting;
- weakness or numbness of an arm or a leg;
- weakness or tiredness;
- yellowing of the skin or eyes;
