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Amiloride Indication.
For the treatment of high blood pressure and management of edema.
Amiloride Contraindications.
Anuria.
Hypersensitivity to this product or to other sulfonamide-derived drugs.
Amiloride Prescription.
The combination of amiloride and hydrochlorothiazide, a 'water pill,' is prescribed to treat high blood pressure and fluid retention caused by various conditions, including heart disease. It causes the kidneys to eliminate unneeded water and salt from the body into the urine.
A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It has been used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.
How should Amiloride be used?
The combination of amiloride and hydrochlorothiazide comes as a tablet to take by mouth. It usually is taken once a day in the morning with food.
Amiloride controls high blood pressure but does not cure it.
Thiazides such as hydrochlorothiazide promote water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue.
Amiloride side effects.
- diarrhea;
- difficulty breathing or swallowing;
- dizziness;
- fatigue;
- frequent urination;
- gas;
- headache;
- loss of appetite;
- muscle weakness or cramps;
- skin rash;
- slow or irregular heartbeat;
- sore throat;
- stomach pain;
- unusual bleeding or bruising;
- upset stomach;
- vomiting;
- yellowing of the skin or eyes;
