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Abacavir Indication.
For the treatment of HIV-1 infection, in combination with other antiretroviral agents.
Abacavir Contraindications.
Abacavir tablets and oral solution are contraindicated in patients with previously demonstrated hypersensitivity to abacavir or any other component of the products. Following a hypersensitivity reaction to abacavir, NEVER restart Abacavir or any other abacavir-containing product. Fatal rechallenge reactions have been associated with readministration of abacavir to patients with a prior history of a hypersensitivity reaction to abacavir. Abacavir tablets and oral solution are contraindicated in patients with moderate or severe hepatic impairment.
Abacavir Prescription.
Abacavir is prescribed in combination with other prescription to treat human immunodeficiency virus (HIV) infection in patients with or without acquired immunodeficiency syndrome (AIDS). Abacavir is in a class of antiviral prescription called nucleoside reverse transcriptase inhibitors (NRTIs). It works by slowing the spread of HIV infection in the body. Abacavir is not a cure and may not decrease the number of HIV-related illnesses. Abacavir does not prevent the spread of HIV to other people.
Abacavir is the most powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
How should Abacavir be used?
Abacavir comes as a tablet and a solution (liquid) to take by mouth. It is usually taken twice a day with or without food. To help you remember to take abacavir, take it around the same time every day. Take abacavir exactly as directed.
Before taking abacavir, carefully read the manufacturer's prescription guide that comes with it.
Abacavir is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Abacavir is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated.
Abacavir side effects.
- bruises in the mouth;
- diarrhea;
- difficulty falling asleep or staying asleep;
- headache;
- loss of appetite;
- muscle or joint pain;
- pain, burning, or tingling in the hands or feet;
- pink eye;
- swelling of the hands, feet, ankles, or lower legs;
- tiredness;
- upset stomach;
- vomiting;
